INFLAMMATION😖 INTRODUCTION DEFINITION AND CAUSES. Inflammation is defined asthe local response of living mammalian tissues to injury dueto any agent. It is a body defense reaction in order to eliminateor limit the spread of injurious agent, followed by removal of the necrosed cells and tissues. The agents causing inflammation may be as under: 1. Infective agents like bacteria, viruses and their toxins, fungi, parasites. 2. Immunological agents like cell-mediated and antigenantibody reactions. 3. Physical agents like heat, cold, radiation, mechanical trauma. 4. Chemical agents like organic and inorganic poisons. 5. Inert materials such as foreign bodies. Thus, inflammation is distinct from infection—while inflammation is a protective response by the body to variety of etiologic agents (infectious or non-infectious), while infection is invasion into the body by harmful microbes and their resultant ill-effects by toxins. Inflammation involves 2 basic processes with some overla...
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